Chapter 17. The Endocrine System

17.3 The Pituitary Gland and Hypothalamus

Learning Objectives

By the end of this section, you will be able to:

  • Explain the anatomical and functional relationships of the hypothalamus and the posterior and anterior lobes of the pituitary gland
  • Identify the two hormones released from the posterior pituitary, their target cells, and principal actions
  • Identify the six hormones produced by the anterior lobe of the pituitary gland, their target cells, their principal actions, and regulation by the hypothalamus

The hypothalamus–pituitary complex can be thought of as the “command center” of the endocrine system. This complex secretes several hormones that directly produce responses in target tissues, as well as hormones that regulate the synthesis and secretion of hormones of other glands. In addition, the hypothalamus–pituitary complex coordinates the messages of the endocrine and nervous systems. In many cases stimuli received by the nervous system must pass through the hypothalamus–pituitary complex to release hormones that can initiate a response.

The hypothalamus is a structure of the diencephalon of the brain located anterior and inferior to the thalamus (Figure 17.31). It has both neural and endocrine functions, producing and secreting many hormones. In addition, the hypothalamus is anatomically and functionally related to the pituitary gland (or hypophysis), a bean-sized organ suspended from it by a stem called the infundibulum (or pituitary stalk). The pituitary gland is cradled within the sella turcica of the sphenoid bone of the skull. It consists of two lobes that arise from distinct parts of embryonic tissue: the posterior pituitary (neurohypophysis) is neural tissue, whereas the anterior pituitary (also known as the adenohypophysis [adeno=glandular]) is glandular tissue. The hormones secreted by the posterior and anterior pituitary, and the intermediate zone between the lobes are summarized in Table 3.

 

This illustration shows the hypothalamus-pituitary complex, which is located at the base of the brain and shown here from a lateral view. The hypothalamus lies inferior and anterior to the thalamus, which is sits atop the brainstem. The hypothalamus connects to the pituitary gland by the stalk-like infundibulum. The pituitary gland looks like a sac containing two balls hanging from the infundibulum. The “balls” are the anterior and posterior lobes of the pituitary. Each lobe secretes different hormones in response to signals from the hypothalamus.

Figure 17.31 – Hypothalamus–Pituitary Complex: The hypothalamus region lies inferior and anterior to the thalamus. It connects to the pituitary gland by the stalk-like infundibulum. The pituitary gland consists of an anterior and posterior lobe, with each lobe secreting different hormones in response to signals from the hypothalamus.

Pituitary Hormones (Table 3)
Pituitary lobe Associated hormones Chemical class Effect
Anterior Growth hormone (GH) Protein Promotes growth of body tissues
Anterior Prolactin (PRL) Peptide Promotes milk production from mammary glands
Anterior Thyroid-stimulating hormone (TSH) Glycoprotein Stimulates thyroid hormone release from thyroid
Anterior Adrenocorticotropic hormone (ACTH) Peptide Stimulates hormone release by adrenal cortex
Anterior Follicle-stimulating hormone (FSH) Glycoprotein Stimulates gamete production in gonads
Anterior Luteinizing hormone (LH) Glycoprotein Stimulates androgen production by gonads
Posterior Antidiuretic hormone (ADH) Peptide Stimulates water reabsorption by kidneys
Posterior Oxytocin Peptide Stimulates uterine contractions during childbirth
Intermediate zone Melanocyte-stimulating hormone Peptide Stimulates melanin formation in melanocytes

Posterior Pituitary

The posterior pituitary is actually an extension of the neurons of the paraventricular and supraoptic nuclei of the hypothalamus. The cell bodies of these nuclei are located in the hypothalamus, but their axons descend as the hypothalamic–hypophyseal tract within the infundibulum, and end in axon terminals within the posterior pituitary (Figure 1732).

 

This illustration zooms in on the hypothalamus and the attached pituitary gland. The posterior pituitary is highlighted. Two nuclei in the hypothalamus contain neurosecretory cells that release different hormones. The neurosecretory cells of the paraventricular nucleus release oxytocin (OT) while the neurosecretory cells of the supraoptic nucleus release anti-diuretic hormone (ADH). The neurosecretory cells stretch down the infundibulum into the posterior pituitary. The tube-like extensions of the neurosecretory cells within the infundibulum are labeled the hypothalamophypophyseal tracts. These tracts connect with a web-like network of blood vessels in the posterior pituitary called the capillary plexus. From the capillary plexus, the posterior pituitary secretes the OT or ADH into a single vein that exits the pituitary.

Figure 17.32 – Posterior Pituitary: Neurosecretory cells in the hypothalamus release oxytocin (OT) or ADH into the posterior lobe of the pituitary gland. These hormones are stored or released into the blood via the capillary plexus.

The posterior pituitary gland does not produce hormones, but rather stores and secretes hormones produced by the hypothalamus. Neurons of the paraventricular nucleus produce the hormone oxytocin, whereas neurons of the supraoptic nucleus produce ADH. These hormones travel along the axons into axon terminals within the posterior pituitary. In response to action potentials from the same hypothalamic neurons that produced them, these hormones are released from vesicles within the axon terminals into the bloodstream.

Oxytocin

When fetal development is complete, the peptide-derived hormone oxytocin (tocia- = “childbirth”) stimulates uterine contractions. Throughout most of pregnancy, oxytocin hormone receptors are not expressed at high levels in the uterus. Toward the end of pregnancy, the synthesis of oxytocin receptors in the uterus increases, and the smooth muscle cells of the uterus become more sensitive to its effects. Oxytocin is continually released throughout childbirth through a positive feedback mechanism. As noted earlier, oxytocin prompts uterine contractions that push the fetal head toward the cervix. In response, cervical stretching stimulates additional oxytocin to be synthesized by the hypothalamus and released from the posterior pituitary. This increases the intensity and effectiveness of uterine contractions and prompts additional stretching of the cervix. This positive feedback loop continues until birth.

Although the mother’s high blood levels of oxytocin begin to decrease immediately following birth, oxytocin continues to play a role in maternal and newborn health. First, oxytocin is necessary for the milk ejection reflex (commonly referred to as “let-down”) in breastfeeding women. As the newborn begins suckling, sensory receptors in the nipples transmit signals to the hypothalamus. In response, oxytocin is secreted and released into the bloodstream. Within seconds, myoepithelial cells around the glandular cells of the mammary glands contract, ejecting milk into the infant’s mouth. Secondly, in both males and females, oxytocin is thought to contribute to parent–newborn bonding, known as attachment. Oxytocin is also thought to be involved in feelings of love and closeness, as well as in the sexual response. In the last examples oxytocin is functioning as a neurotransmitter in the brain.

Antidiuretic Hormone (ADH)

The solute concentration of the blood, or blood osmolarity, may change in response to the consumption of certain foods and fluids, as well as in response to disease, injury, medications, or other factors. Blood osmolarity is constantly monitored by osmoreceptors—specialized cells within the hypothalamus that are particularly sensitive to the concentration of sodium ions and other solutes.

In response to high blood osmolarity, which can occur during dehydration or following a very salty meal, stimulation of osmoreceptors causes neurons in the supraoptic nucleus to signal the posterior pituitary to release antidiuretic hormone (ADH). The target cells of ADH are located in the tubular cells of the kidneys. Its effect is to increase epithelial permeability to water, allowing increased water reabsorption. This increase in water reabsorption has the effect of making the blood more dilute and the urine more concentrated. ADH is also known as vasopressin because in high concentrations, rarely seen except in cases of hemorrhage or shock, it causes constriction of blood vessels, which increases blood pressure by increasing peripheral resistance. The release of ADH is controlled by a negative feedback loop. As blood osmolarity decreases, the hypothalamic osmoreceptors sense the change prompting a corresponding decrease in the secretion of ADH. As a result, less water is reabsorbed from the urine filtrate.

Some drugs can affect the secretion of ADH. For example, alcohol consumption inhibits the release of ADH, resulting in increased urine production that can eventually lead to the dehydration of a hangover. A disease called diabetes insipidus is characterized by chronic underproduction of ADH that causes chronic dehydration. Because little ADH is produced and secreted, not enough water is reabsorbed by the kidneys. Although patients feel thirsty, and increase their fluid consumption, this doesn’t effectively decrease the solute concentration in their blood because ADH levels are not high enough to trigger water reabsorption in the kidneys. Electrolyte imbalances can occur in severe cases of diabetes insipidus. The opposite occurs in a condition called SIADH (syndrome of inappropriate antidiuretic hormone), ADH is secreted at extremely high levels leading to extremely concentrated urine producing a dangerously low blood osmolarity known as water intoxication.

Anterior Pituitary

The anterior pituitary originates from epithelial tissue derived from an invagination of the oral mucusa in the embryo which migrates toward the brain during fetal development. There are three regions: the pars distalis is the most anterior, the pars intermedia is adjacent to the posterior pituitary, and the pars tuberalis is a slender “tube” that wraps the infundibulum.

Recall that the posterior pituitary does not synthesize hormones, but merely stores them. In contrast, the anterior pituitary does manufacture hormones. Like the posterior pituitary the release of hormones from the anterior pituitary is controlled by the hypothalamus. This control is mediated by secretion of releasing or inhibiting hormones into the blood.

Within the infundibulum is a bridge of capillaries that connects the hypothalamus to the anterior pituitary. This network, called the hypophyseal portal system, allows hypothalamic hormones to be transported to the anterior pituitary without becoming diluted in systemic circulation. This portal system begins with a primary capillary plexus originating from the superior hypophyseal artery, a branches of the internal carotid artery. Blood from the first capillary bed supplies a secondary capillary plexus in the anterior pituitary via the hypophyseal portal veins (see Figure 17.33). Hypothalamic releasing and inhibiting hormones are released into the primary capillary plexus which drain into the portal veins carrying them to the secondary capillary plexus where they stimulate (or inhibit) the endocrine cells of the anterior pituitary. Hormones produced by the anterior pituitary (in response to hypothalamic releasing hormones) enter the secondary capillary plexus continuing into general circulation.

 

This illustration zooms in on the hypothalamus and the attached pituitary gland. The anterior pituitary is highlighted. Three neurosecretory cells are secreting hormones into a web-like network of arteries within the infundibulum. The artery net is labeled the primary capillary plexus of the hypophyseal portal system. The superior hypophysel artery enters the primary capillary plexus from outside of the infundibulum. The hypophyseal portal vein runs down from the primary capillary plexus, through the infundibulum, and connects to the secondary capillary plexus of the hypophyseal portal system. The secondary capillary plexus is located within the anterior pituitary. The hormones released from the neurosecretory cells of the hypothalamus travel through the primary capillary plexus, down the hypophyseal portal vein, and into the secondary capillary plexus. There, the hypothalamus hormones stimulate the anterior pituitary to release its hormones. The anterior pituitary hormones leave the primary capillary plexus from a single vein at the bottom of the anterior lobe.

Figure 17.33 – Anterior Pituitary: The anterior pituitary manufactures seven hormones. The hypothalamus produces separate hormones that stimulate or inhibit hormone production in the anterior pituitary. Hormones from the hypothalamus reach the anterior pituitary via the hypophyseal portal system.

The anterior pituitary produces seven hormones. These are growth hormone (GH), thyroid-stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), beta endorphin, and prolactin. Of the hormones of the anterior pituitary, TSH, ACTH, FSH, and LH are collectively referred to as tropic hormones (trope- = “turning”) because they stimulate or inhibit secretion of hormones from other glands.

Growth Hormone

Growth hormone (GH), also called somatotropin regulates the growth of the human body, protein synthesis, and cellular replication. Its primary function is anabolic; it promotes protein synthesis and tissue building through direct and indirect mechanisms (Figure 17.34). GH levels are controlled by the release of GHRH and GHIH (also known as somatostatin) from the hypothalamus.

 

This flow chart illustrates the hormone cascade that stimulates human growth. In step 1, the hypothalamus releases growth hormone-releasing hormone (GHRH). GHRH travels into the primary capillary plexus of the anterior pituitary, where it stimulates the anterior pituitary to release growth hormone (GH). The release of growth hormone causes three types of effects. In the glucose-sparing effect, GH stimulates adipose cells to break down stored fat, fueling the growth effects (discussed next). The target cells for the glucose-sparing effects are adipose cells. In the growth effects, GH increases the uptake of amino acids from the blood and enhances cellular proliferation while also reducing apoptosis. The target cells for the growth effects are bone cells, muscle cells, nervous system cells, and immune system cells. In the diabetogenic effect, GH stimulates the liver to break down glycogen into glucose, fueling the growth effects. The liver also releases IGF in response to GH. The IGF further stimulates the growth effects but also negatively feeds back to the hypothalamus. When high IGF one levels are perceived by the hypothalamus, it releases growth hormone inhibiting hormone (GHIH). GHIH inhibits GH release by the anterior pituitary.

Figure 17.34 – Hormonal Regulation of Growth: Growth hormone (GH) directly accelerates the rate of protein synthesis in skeletal muscle and bones. Insulin-like growth factor 1 (IGF-1) is activated by growth hormone and indirectly supports the formation of new proteins in muscle cells and bone.

A glucose-sparing effect occurs when GH stimulates lipolysis, or the breakdown of adipose tissue, releasing fatty acids into the blood. As a result, many tissues switch from glucose to fatty acids as their main energy source, which means that less glucose is taken up from the bloodstream.

GH also initiates the diabetogenic effect in which GH stimulates the liver to break down glycogen to glucose, which is then released into the blood. The name “diabetogenic” is derived from the similarity in elevated blood glucose levels observed between individuals with untreated diabetes mellitus and individuals experiencing GH excess. Blood glucose levels rise as the result of a combination of glucose-sparing and diabetogenic effects.

GH indirectly mediates growth and protein synthesis by triggering the liver and other tissues to produce a group of proteins called insulin-like growth factors (IGFs). These proteins enhance cellular proliferation and inhibit apoptosis, or programmed cell death. IGFs stimulate cells to increase their uptake of amino acids from the blood for protein synthesis. Skeletal muscle and cartilage cells are particularly sensitive to stimulation from IGFs.

Dysfunction of the endocrine system’s control of growth can result in several disorders. For example, gigantism is a disorder caused by the hypersecretion of GH before the growth plates have closed resulting in excessive growth of all bones. Hypersecretion of GH after the growth plates have closed results in a condition called acromegaly, a disorder that results in the growth of bones in the face, hands, and feet. Abnormally low levels of GH in children can cause growth impairment—a disorder called pituitary dwarfism (also known as growth hormone deficiency) which affects all bones. Achondroplastic dwarfism affects only the bones with growth plates (long bones) resulting in short arms and legs with normal sized trunk and head.

Thyroid-Stimulating Hormone

The activity of the thyroid gland is regulated by thyroid-stimulating hormone (TSH), also called thyrotropin. TSH is released from the anterior pituitary in response to thyrotropin-releasing hormone (TRH) from the hypothalamus. As will be discussed shortly, it triggers the secretion of thyroid hormones by the thyroid gland. In a classic negative feedback loop, elevated levels of thyroid hormones in the bloodstream then trigger a drop in production of TRH and TSH.

Adrenocorticotropic Hormone

The adrenocorticotropic hormone (ACTH), also called corticotropin, stimulates the adrenal cortex (the more superficial “bark” of the adrenal glands) to secrete corticosteroid hormones such as cortisol. ACTH come from a precursor molecule known as pro-opiomelanotropin (POMC) which produces several biologically active molecules when cleaved, including ACTH, melanocyte-stimulating hormone, and the brain opioid peptides known as endorphins.

The release of ACTH is regulated by the corticotropin-releasing hormone (CRH) from the hypothalamus in response to normal physiologic rhythms. A variety of stressors can also influence its release, and the role of ACTH in the stress response is discussed later in this chapter.

Follicle-Stimulating Hormone and Luteinizing Hormone

The endocrine glands secrete a variety of hormones that control the development and regulation of the reproductive system (these glands include the anterior pituitary, the adrenal cortex, and the gonads—the testes in males and the ovaries in females). Much of the development of the reproductive system occurs during puberty and is marked by the development of sex-specific characteristics in both male and female adolescents. Puberty is initiated by gonadotropin-releasing hormone (GnRH), a hormone produced and secreted by the hypothalamus. GnRH stimulates the anterior pituitary to secrete gonadotropins—hormones that regulate the function of the gonads. The levels of GnRH are regulated through a negative feedback loop; high levels of reproductive hormones inhibit the release of GnRH. Throughout life, gonadotropins regulate reproductive function.

The gonadotropins include two glycoprotein hormones: follicle-stimulating hormone (FSH) stimulates the production and maturation of sex cells, or gametes, including ova in women and sperm in men. FSH also promotes ovarian follicular growth in women; these follicles then release estrogens. Luteinizing hormone (LH) triggers ovulation in women, as well as the production of estrogens and progesterone by the ovaries. LH stimulates production of testosterone by the male testes.

Prolactin

As its name implies, prolactin (PRL) promotes lactation (milk production) in women. After birth, it stimulates the mammary glands to produce breast milk. However, the effects of prolactin depend heavily upon the permissive effects of estrogens, progesterone, and other hormones. And as noted earlier, the let-down of milk occurs in response to stimulation from oxytocin.

In a non-pregnant woman, prolactin secretion is inhibited by prolactin-inhibiting hormone (PIH), which is actually the neurotransmitter dopamine, released from neurons in the hypothalamus. Only during pregnancy do prolactin levels rise primarily in response to a decrease in inhibition by PIH and partially due to stimulation by prolactin-releasing hormone (PRH) from the hypothalamus.

Intermediate Pituitary: Melanocyte-Stimulating Hormone

The cells in the zone between the pituitary lobes secrete a hormone known as melanocyte-stimulating hormone (MSH) that is formed by cleavage of the pro-opiomelanocortin (POMC) precursor protein. Local production of MSH in the skin is responsible for melanin production in response to UV light exposure. The role of MSH made by the pituitary is more complicated. For instance, people with lighter skin generally have the same amount of MSH as people with darker skin. Nevertheless, this hormone is capable of darkening of the skin by inducing melanin production in the skin’s melanocytes. Women also show increased MSH production during pregnancy; in combination with estrogens, it can lead to darker skin pigmentation, especially the skin of the areolas and labia minora. Figure 17.35 is a summary of the pituitary hormones and their principal effects.

 

Figure 17.35 – Major Pituitary Hormones: Major pituitary hormones and their target organs.

External Website

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Visit this link to watch an animation showing the role of the hypothalamus and the pituitary gland. Which hormone is released by the pituitary to stimulate the thyroid gland?

 

Chapter Review

The hypothalamus–pituitary complex is located in the diencephalon of the brain. The hypothalamus and the pituitary gland are connected by a structure called the infundibulum, which contains vasculature and nerve axons. The pituitary gland is divided into two distinct structures with different embryonic origins. The posterior lobe houses the axon terminals of hypothalamic neurons. It stores and releases into the bloodstream two hypothalamic hormones: oxytocin and antidiuretic hormone (ADH). The anterior lobe is connected to the hypothalamus by vasculature in the infundibulum and produces and secretes six hormones. Their secretion is regulated, however, by releasing and inhibiting hormones from the hypothalamus. The six anterior pituitary hormones are: growth hormone (GH), thyroid-stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (PRL).

 

Interactive Link Questions

Visit this link to watch an animation showing the role of the hypothalamus and the pituitary gland. Which hormone is released by the pituitary to stimulate the thyroid gland?

Thyroid-stimulating hormone.

 

Review Questions

Critical Thinking Questions

1. Compare and contrast the anatomical relationship of the anterior and posterior lobes of the pituitary gland to the hypothalamus.

2. Name the target tissues for prolactin.

Glossary

acromegaly
disorder in adults caused when abnormally high levels of GH trigger growth of bones in the face, hands, and feet
adrenocorticotropic hormone (ACTH)
anterior pituitary hormone that stimulates the adrenal cortex to secrete corticosteroid hormones (also called corticotropin)
antidiuretic hormone (ADH)
hypothalamic hormone that is stored by the posterior pituitary and that signals the kidneys to reabsorb water
follicle-stimulating hormone (FSH)
anterior pituitary hormone that stimulates the production and maturation of sex cells
gigantism
disorder in children caused when abnormally high levels of GH prompt excessive growth
gonadotropins
hormones that regulate the function of the gonads
growth hormone (GH)
anterior pituitary hormone that promotes tissue building and influences nutrient metabolism (also called somatotropin)
hypophyseal portal system
network of blood vessels that enables hypothalamic hormones to travel into the anterior lobe of the pituitary without entering the systemic circulation
hypothalamus
region of the diencephalon inferior to the thalamus that functions in neural and endocrine signaling
infundibulum
stalk containing vasculature and neural tissue that connects the pituitary gland to the hypothalamus (also called the pituitary stalk)
insulin-like growth factors (IGF)
protein that enhances cellular proliferation, inhibits apoptosis, and stimulates the cellular uptake of amino acids for protein synthesis
luteinizing hormone (LH)
anterior pituitary hormone that triggers ovulation and the production of ovarian hormones in females, and the production of testosterone in males
osmoreceptor
hypothalamic sensory receptor that is stimulated by changes in solute concentration (osmotic pressure) in the blood
oxytocin
hypothalamic hormone stored in the posterior pituitary gland and important in stimulating uterine contractions in labor, milk ejection during breastfeeding, and feelings of attachment (also produced in males)
pituitary dwarfism
disorder in children caused when abnormally low levels of GH result in growth retardation
pituitary gland
bean-sized organ suspended from the hypothalamus that produces, stores, and secretes hormones in response to hypothalamic stimulation (also called hypophysis)
prolactin (PRL)
anterior pituitary hormone that promotes development of the mammary glands and the production of breast milk
thyroid-stimulating hormone (TSH)
anterior pituitary hormone that triggers secretion of thyroid hormones by the thyroid gland (also called thyrotropin)

Solutions

Answers for Critical Thinking Questions

  1. The anterior lobe of the pituitary gland is connected to the hypothalamus by vasculature, which allows regulating hormones from the hypothalamus to travel to the anterior pituitary. In contrast, the posterior lobe is connected to the hypothalamus by a bridge of nerve axons called the hypothalamic–hypophyseal tract, along which the hypothalamus sends hormones produced by hypothalamic nerve cell bodies to the posterior pituitary for storage and release into the circulation.
  2. The mammary glands are the target tissues for prolactin.